# 【2.5.1】Emini surface accessibility scale

Description: The calculation was based on surface accessibility scale on a product instead of an addition within the window. The accessibility profile was obtained using the formulae Sn = (n+4+i ) (0.37)^-6 where Sn is the surface probability, dn is the fractional surface probability value, and i vary from 1 to 6. A hexapeptide sequence with Sn greater than 1.0 indicates an increased probability for being found on the surface.

A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
0.49	0.26	0.81	0.84	0.42	0.48	0.66	0.34	0.97	0.4	0.48	0.78	0.75	0.84	0.95	0.65	0.7	0.36	0.51	0.76


Emini等人（5,6）在脊髓灰质炎病毒VP1蛋白上鉴定了几个脊髓灰质炎病毒1型特异性中和抗原性位点。 包含这些位点氨基酸序列的合成肽能够直接诱导病毒中和抗体反应，或者在接种亚免疫原剂量的完整病毒体后引发这种免疫反应

## 参考资料

• Emini EA, Hughes JV, Perlow DS, Boger J. Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide. J Virol. 1985 Sep;55(3):836-9.
• http://tools.iedb.org/bcell/help/