【2.1】药物相互作用系数CDI

coefficient of drug interaction (CDI)

CDI was used to calculate synergy with the combination using mean tumor weight measurements:

CDI = AB/(A×B)

where AB is the ratio of the 2-drug combination group to the control group and A or B is the ratio of the single drug group to the control group.

  • CDI < 1 indicates synergism
  • especially CDI < 0.7 indicates a significantly synergistic effect
  • CDI = 1 indicates additivity
  • CDI > 1 indicates antagonism.

参考资料

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