【2.1】药物相互作用系数CDI

coefficient of drug interaction (CDI)

CDI was used to calculate synergy with the combination using mean tumor weight measurements:

CDI = AB/(A×B)

where AB is the ratio of the 2-drug combination group to the control group and A or B is the ratio of the single drug group to the control group.

• CDI < 1 indicates synergism
• especially CDI < 0.7 indicates a significantly synergistic effect
• CDI = 1 indicates additivity
• CDI > 1 indicates antagonism.

参考资料

• https://www.pnas.org/content/117/3/1666